While it will work it seems like a big waste with a 2080Ti for non-3D applications.
I would think a single 2080 Ti hardly notice a couple of extra screens with 'normal' windows...
Have not tried a two GPU-card setup but I assume it would work with different cards too as long as you don't intend to use SLI. (So you could at least chose a cheeper card)
Most motherboards will reduce the speed (number of lanes) on the slots if more cards are added and that might reduce the performance on the main card.